Premedication with 20 mg dexamethasone effectively prevents relapse of extensive skin rash associated with gemcitabine monotherapy.
نویسندگان
چکیده
Gemcitabine treatment is commonly associated with skin rash, with a reported incidence of 7%–30% [1–3]; however, there exists only one prior report describing the management of gemcitabine-associated rash in the English-language literature [1]. When an extensive skin rash develops, both the patient and physician may experience anxiety about continuing gemcitabine treatment. For patients with a toxic drug-induced rash, continued administration of that drug may exacerbate the rash and put the patient at the risk of a more severe toxic event, such as toxic epidermal necrosis (TEN). From April 2008 to April 2009, we treated 107 patients with gemcitabine monotherapy and experienced four T a b le 1 . P at ie n t ch ar ac te ri st ic s
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ورودعنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2010